More than 150 dogs were removed from two separate locations owned by a large, substandard, unlicensed breeding facility in Lake City.
Dogs from the facility, called JRT John's Jack Russell and Shiba Inu Kennel, were removed by an ASPCA response team.
The animals' removal is a result of civil legal action involving the Missaukee Co. Sheriff's Office and the Roscommon County Animal Shelter.
The dogs were mostly Jack Russell terriers and Shiba Inus. They were discovered living in outdoor enclosures with little protection from the elements.
Officials from ASPCA say many of the dogs had no access to clean drinking water or proper shelter, with plastic carriers being their only refuge from the elements.
ASPCA called the facility a puppy mill, which is considered a large-scale breeding operation where "profit is given priority over the well-being of the animals."
"Puppy mill dogs may suffer from living in a variety of inhumane conditions including unsanitary conditions, inadequate veterinary care, and lack of basic necessities and socialization," said Kathryn Destreza, director of Investigations for ASPCA Field Investigations and Response.
"This case has been years in the making and we felt strongly that something had to be done to protect these animals," said Sheriff Jim Bosscher.
Officials say dogs requiring medical attention are being transported to a nearby temporary shelter. Those dogs that are medically and behaviorally sound will be immediately placed by the Roscommon County Animal Shelter.