A 69-year-old of Marion was pronounced dead at the scene after running off the road in a pick-up truck and hitting a tree in Winterfield Township.
Lawrence Jackson, the driver, and two other passengers were traveling northbound in a green 1994 Ford Ranger on Cook Rd. north of Haskell Lake Rd. on Monday.
The Clare County Central Dispatch responded to the accident at 11:39 a.m.
Passenger Shirley Parsell, 39, was transported by ambulance to Mercy Hospital in Cadillac for treatment.
Ashton McLeod, 8, was also in the vehicle and was flown by helicopter to DeVos Children's Hospital in Grand Rapids.
McLeod was sitting in the middle of the pickup not wearing a seatbelt.
Both Parsell and McLeod remain in the hospital for treatment.
The accident remains under investigation.