Florida and Michigan will open the 2017 season in the Cowboys Classic in Arlington, Texas.
The prime-time game is scheduled for Saturday, Sept. 2.
It will be Florida's first regular-season, non-conference game outside the Sunshine State since the Gators lost at Syracuse in 1991.
Florida athletic director Jeremy Foley says he "thought it was something that our fans would embrace, our program would embrace."
Michigan coach Brady Hoke says the game is "a great way to reach our fan base in the south and to continue to expand our recruiting efforts in the state of Texas. Our goal is to have as many Michigan fans at the game as possible."
Each school will receive 25,000 tickets for the neutral-site game at AT&T Stadium, home to the NFL's Dallas Cowboys.